Fmoc-L-His(Trt)-OH
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Used in the synthesis of GLP-1 peptides and other pharmaceutical polypeptides, Fmoc-L-His(Trt)-OH (CAS No. 109425-51-6) is a histidine derivative with dual protection: an Fmoc group on the N-terminus and a trityl (Trt) group on the imidazole ring. This configuration prevents undesired side reactions during stepwise peptide assembly, especially under solid-phase conditions. The compound has a molecular weight of 619.7 g/mol and a molecular formula of C₄₀H₃₃N₃O₄. It is supplied as a white powder with 99% min purity and should be stored sealed at 2–8 °C to preserve its stability and reactivity throughout the synthesis process.
- CAS No.: 109425-51-6
- Molecular Formula: C₄₀H₃₃N₃O₄
- Purity: 99% min
- Appearance White powder
- Molecular Weight 619.7 g/mol
- Density 1.2 ± 0.1 g/cm³
- Boiling Point 811.7 ± 65.0 °C at 760 mmHg
- Melting Point 150–155 °C (lit.)
- Flash Point 444.7 ± 34.3 °C
- Packaging 25 kg / fibre drum
- Storage Conditions Sealed, 2–8 °C
- Customs Code 29332990
- Product Name
- Fmoc-His(Trt)-OH;
- N-Fmoc-N'-trityl-L-histidine;
- (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid; Nalpha-Fmoc-Nim-trityl-L-histidine
- Production Capacity 3 ton/month
- Applications Raw material for GLP-1 peptides, polypeptides, Semaglutide, and Tirzepatide